Cryo-EM structure of human high-voltage activated L-type calcium channel CaV1.2 (apo)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8hlp
Q-score: 0.435
Wei Y, Yu Z, Wang L, Li X, Li N, Bai Q, Wang Y, Li R, Meng Y, Xu H, Wang X, Dong Y, Huang Z, Zhang XC, Zhao Y
Nat Commun (2024) 15 pp. 2772-2772 [ Pubmed: 38555290 DOI: doi:10.1038/s41467-024-47116-8 ]
- Hexadecane (226 Da, Ligand)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Isoform 2c of voltage-dependent l-type calcium channel subunit beta-2 (70 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Voltage-dependent l-type calcium channel subunit alpha (243 kDa, Protein from Homo sapiens)
- Cav3.3 (Complex from Homo sapiens)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (121 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8hma
Q-score: 0.424
Wei Y, Yu Z, Wang L, Li X, Li N, Bai Q, Wang Y, Li R, Meng Y, Xu H, Wang X, Dong Y, Huang Z, Zhang XC, Zhao Y
Nat Commun (2024) 15 pp. 2772-2772 [ Pubmed: 38555290 DOI: doi:10.1038/s41467-024-47116-8 ]
- Hexadecane (226 Da, Ligand)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Isoform 2c of voltage-dependent l-type calcium channel subunit beta-2 (70 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 6,6',7,12-tetramethoxy-2,2'-dimethyl-1beta-3,4-didehydroberbaman (620 Da, Ligand)
- Voltage-dependent l-type calcium channel subunit alpha (243 kDa, Protein from Homo sapiens)
- Beta-d-mannopyranose (180 Da, Ligand)
- Cav1.2alpha2delta1beta2b (Complex from Homo sapiens)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (121 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8hmb
Q-score: 0.472
Wei Y, Yu Z, Wang L, Li X, Li N, Bai Q, Wang Y, Li R, Meng Y, Xu H, Wang X, Dong Y, Huang Z, Zhang XC, Zhao Y
Nat Commun (2024) 15 pp. 2772-2772 [ Pubmed: 38555290 DOI: doi:10.1038/s41467-024-47116-8 ]
- Hexadecane (226 Da, Ligand)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Isoform 2c of voltage-dependent l-type calcium channel subunit beta-2 (70 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- (3r)-1-benzylpiperidin-3-yl methyl (2r,3r,4r,5r,6s)-2,6-dimethyl-4-(3-nitrophenyl)piperidine-3,5-dicarboxylate (506 Da, Ligand)
- Voltage-dependent l-type calcium channel subunit alpha (243 kDa, Protein from Homo sapiens)
- Cav3.3 (Complex from Homo sapiens)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (121 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of the [Pyr1]-apelin-13-bound human APLNR-Gi complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8xzg
Q-score: 0.495
Wang WW, Ji SY, Zhang W, Zhang J, Cai C, Hu R, Zang SK, Miao L, Xu H, Chen LN, Yang Z, Guo J, Qin J, Shen DD, Liang P, Zhang Y, Zhang Y
Cell (2024) 187 pp. 1460-1475.e20 [ DOI: doi:10.1016/j.cell.2024.02.004 Pubmed: 38428423 ]
- Apelin receptor (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cryo-em structure of the [pyr1]-apelin-13-bound human aplnr-gi complex (Complex from Homo sapiens)
- Apelin-13 (1 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
Cryo-EM structure of the WN561-bound human APLNR-Gi complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8xzf
Q-score: 0.578
Wang WW, Ji SY, Zhang W, Zhang J, Cai C, Hu R, Zang SK, Miao L, Xu H, Chen LN, Yang Z, Guo J, Qin J, Shen DD, Liang P, Zhang Y, Zhang Y
Cell (2024) 187 pp. 1460-1475.e20 [ DOI: doi:10.1016/j.cell.2024.02.004 Pubmed: 38428423 ]
- Scfv16 (26 kDa, Protein from synthetic construct)
- Cryo-em structure of the wn561-bound human aplnr-gi complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Apelin receptor (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Wn561 (1 kDa, Protein from synthetic construct)
Cryo-EM structure of the MM07-bound human APLNR-Gi complex
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8xzh
Q-score: 0.649
Wang WW, Ji SY, Zhang W, Zhang J, Cai C, Hu R, Zang SK, Miao L, Xu H, Chen LN, Yang Z, Guo J, Qin J, Shen DD, Liang P, Zhang Y, Zhang Y
Cell (2024) 187 pp. 1460-1475.e20 [ DOI: doi:10.1016/j.cell.2024.02.004 Pubmed: 38428423 ]
- Mm07 (1 kDa, Protein from synthetic construct)
- Cryo-em structure of the mm07-bound human aplnr-gi complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (27 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Apelin receptor (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
Cryo-EM structure of the CMF-019-bound human APLNR-Gi complex
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8xzi
Q-score: 0.588
Wang WW, Ji SY, Zhang W, Zhang J, Cai C, Hu R, Zang SK, Miao L, Xu H, Chen LN, Yang Z, Guo J, Qin J, Shen DD, Liang P, Zhang Y, Zhang Y
Cell (2024) 187 pp. 1460-1475.e20 [ DOI: doi:10.1016/j.cell.2024.02.004 Pubmed: 38428423 ]
- Scfv16 (26 kDa, Protein from synthetic construct)
- (3~{s})-5-methyl-3-[[1-pentan-3-yl-2-(thiophen-2-ylmethyl)benzimidazol-5-yl]carbonylamino]hexanoic acid (455 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cryo-em structure of the cmf-019-bound human aplnr-gi complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Apelin receptor (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
Cryo-EM structure of the WN353-bound human APLNR-Gi complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8xzj
Q-score: 0.509
Wang WW, Ji SY, Zhang W, Zhang J, Cai C, Hu R, Zang SK, Miao L, Xu H, Chen LN, Yang Z, Guo J, Qin J, Shen DD, Liang P, Zhang Y, Zhang Y
Cell (2024) 187 pp. 1460-1475.e20 [ DOI: doi:10.1016/j.cell.2024.02.004 Pubmed: 38428423 ]
- Scfv16 (26 kDa, Protein from synthetic construct)
- Cryo-em structure of the wn353-bound human aplnr-gi complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Wn353 (1 kDa, Protein from synthetic construct)
- Apelin receptor (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
The cryo-EM structure of insect gustatory receptor Gr43a from Drosophila melanogaster
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8jm9
Q-score: 0.593
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 8jma
Q-score: 0.637